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CCI 007
CAS No. 939228-52-1
CCI 007 ( —— )
产品货号. M24990 CAS No. 939228-52-1
CCI 007 是 MLL-r、CALM-AF10 和 SET-NUP214 白血病的选择性抑制剂，针对 MLL-r 白血病细胞系 PER-485 的 IC50 为 3.5 uM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥729 | 有现货 |
|
| 5MG | ￥1126 | 有现货 |
|
| 10MG | ￥1798 | 有现货 |
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| 25MG | ￥3548 | 有现货 |
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| 50MG | ￥5257 | 有现货 |
|
| 100MG | ￥7501 | 有现货 |
|
| 500MG | ￥15147 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称CCI 007
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述CCI 007 是 MLL-r、CALM-AF10 和 SET-NUP214 白血病的选择性抑制剂，针对 MLL-r 白血病细胞系 PER-485 的 IC50 为 3.5 uM。
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产品描述CCI 007 is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia with IC50 of 3.5 uM against MLL-r leukemia cell line PER-485
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体外实验CCI-007 is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia.Following CCI-007 treatment for 24h, significant mitochondrial depolarization was observed in PER-485 cells as evidenced by a shift in JC-1 signal. CCI-007 alters the characteristic MLL-r gene expression signature in sensitive cells with downregulation of the expression of HOXA9, MEIS1, CMYC and BCL2.Resistance to CCI-007 can occur by upregulation of MLL target gene expression. :Cell Viability Assay Cell Line:PER-485, MOLM-13, MV4;11 cells.Concentration:5 μM.Incubation Time:24 h.Result:Induced apoptosis.
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体内实验——
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同义词——
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通路Chromatin/Epigenetic
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靶点Histone Demethylase
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受体MLL-r
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研究领域——
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适应症——
化学信息
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CAS Number939228-52-1
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分子量336.36
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分子式C15H16N2O5S
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纯度>98% (HPLC)
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溶解度DMSO:10 mM
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SMILESO=C(OCC)COC(C=CC(C=C1SC(N)=NC1=O)=C2)=C2OC
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Somers K , Chudakova D A , Middlemiss S , et al. CCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements[J]. Oncotarget, 2016, 7(29):46067-46087.
